FDA-Approved Specifically for Weight Loss
Zepbound® (Tirzepatide)Zepbound® (tirzepatide) is FDA-approved specifically for chronic weight management—the same powerful dual-action medication as Mounjaro, now with official weight loss approval.
Avg weight loss
20-22%
vs retail
74%
up to 74% savings
Frequency
Once Weekly
GLP-1 medications are priced separately: Ozempic starts at $175/month and Zepbound starts at $275/month, up to 75% less than retail pharmacy prices.
How Zepbound works
Zepbound activates both GIP and GLP-1 receptors, creating a dual-action effect that surpasses traditional single-receptor weight loss medications. It reduces hunger signals, increases feelings of fullness, slows digestion, and improves how your body processes food—all working together for maximum weight loss.
Clinical evidence
The SURMOUNT trials showed participants on Zepbound lost an average of 22.5% of their body weight—approximately 52 pounds for the average participant—making it the most effective FDA-approved weight loss medication.
Benefits at PWL
- FDA-approved specifically for weight loss
- Highest average weight loss of any approved medication (20-22%)
- Dual GIP/GLP-1 mechanism for superior results
- Once-weekly convenient injection
- Dramatic reduction in hunger and cravings
- Improvements in blood pressure and cholesterol
- Better energy levels as weight decreases
- Reduced risk of weight-related diseases
Common side effects
- Nausea (most common in first weeks, typically resolves)
- Diarrhea or vomiting
- Constipation
- Abdominal discomfort
- Injection site reactions
Side effects are typically mild and improve over time. Your provider guides you on managing any symptoms during your monthly check-ins.
Who Should Not Take Zepbound
- ⚠Personal history of pancreatitis
- ⚠Personal or family history of medullary thyroid cancer (MTC)
- ⚠Personal or family history of multiple endocrine neoplasia type 2 (MEN2)
- ⚠Pregnant or breastfeeding patients
- ⚠Patients with severe gastrointestinal motility disorders, with case-by-case provider review
Black Box Warning
Tirzepatide causes thyroid C-cell tumors in rodents. It is not known whether Zepbound causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans. Zepbound is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Patients should be counseled regarding the potential risk of MTC and symptoms of thyroid tumors.
Medically reviewed by Dr. Scott Friedman, MD ·
Common Questions About Zepbound
How much weight can I lose with Zepbound?
Clinical trials (SURMOUNT for Zepbound, SURPASS for Mounjaro) showed average weight loss of 20-22% with tirzepatide. For someone starting at 250 lbs, that is approximately 50-55 pounds. Individual results vary based on starting weight, adherence, dose, and lifestyle factors.
What are the most common Zepbound side effects?
Nausea, mild GI changes, constipation, fatigue, and occasional acid reflux are most common, especially during the first few weeks and after dose increases. Most side effects are mild and resolve with dose adjustment, hydration, increased fiber and protein, and time. Your provider monitors closely throughout treatment.
Is Zepbound brand-name or compounded?
Premier Weight Loss prescribes only brand-name, FDA-approved Zepbound. We never use compounded alternatives. All medication arrives in original manufacturer packaging.
How much does Zepbound cost at Premier Weight Loss?
Zepbound starts at $275/month at Premier Weight Loss, up to 75% less than retail pharmacy prices. Final pricing depends on dose and is confirmed with your provider during the consultation. Available via virtual care, shipped to your Indiana address.
How is Zepbound different from the other GLP-1s you prescribe?
Zepbound (tirzepatide) is a dual-action medication that activates both GIP and GLP-1 receptors, which is why trial weight loss is higher than semaglutide (Wegovy, Ozempic). Your provider will recommend the best option based on your goals, health profile, and treatment response.
Other Medications We Prescribe
Ready to start with Zepbound?
Reserve a $45 consult. Your provider will confirm the right medication and dose for you.