The Original Semaglutide That Started It All
Ozempic® (Semaglutide)Ozempic® (semaglutide) is FDA-approved for type 2 diabetes and widely prescribed for weight loss. The medication that sparked the GLP-1 weight loss revolution.
Avg weight loss
14-15%
vs retail
82%
up to 82% savings
Frequency
Once Weekly
GLP-1 medications are priced separately: Ozempic starts at $175/month and Zepbound starts at $275/month, up to 75% less than retail pharmacy prices.
How Ozempic works
Ozempic contains semaglutide, which mimics your body's natural GLP-1 hormone. It reduces appetite by acting on hunger centers in the brain, slows stomach emptying so you feel full longer, and improves blood sugar control. This triple action makes it highly effective for both diabetes and weight loss.
Clinical evidence
In the SUSTAIN trials, patients taking the highest Ozempic dose (2mg) lost an average of 14-15% of their body weight as a secondary benefit while treating diabetes.
Benefits at PWL
- Well-established safety and efficacy profile
- Significant 14-15% average weight loss
- Excellent blood sugar control for diabetics
- Once-weekly injection convenience
- Cardiovascular protection
- Most affordable GLP-1 option
- Years of real-world usage data
- Often available when newer medications face shortages
Common side effects
- Nausea (usually mild and temporary)
- Vomiting or diarrhea
- Constipation
- Abdominal pain
- Injection site reactions
Side effects are typically mild and improve over time. Your provider guides you on managing any symptoms during your monthly check-ins.
Who Should Not Take Ozempic
- ⚠Personal history of pancreatitis
- ⚠Personal or family history of medullary thyroid cancer (MTC)
- ⚠Personal or family history of multiple endocrine neoplasia type 2 (MEN2)
- ⚠Pregnant or breastfeeding patients
- ⚠Patients with severe gastrointestinal motility disorders, with case-by-case provider review
Black Box Warning
Semaglutide causes thyroid C-cell tumors in rodents. It is not known whether Ozempic causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans. Ozempic is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Patients should be counseled regarding the potential risk of MTC and symptoms of thyroid tumors.
Medically reviewed by Dr. Scott Friedman, MD ·
Common Questions About Ozempic
How much weight can I lose with Ozempic?
Clinical trials (STEP for Wegovy, SUSTAIN for Ozempic) showed average weight loss of 15-17% with semaglutide. For someone starting at 250 lbs, that is approximately 37-42 pounds. Individual results vary based on starting weight, adherence, dose, and lifestyle factors.
What are the most common Ozempic side effects?
Nausea, mild GI changes, constipation, fatigue, and occasional acid reflux are most common, especially during the first few weeks and after dose increases. Most side effects are mild and resolve with dose adjustment, hydration, increased fiber and protein, and time. Your provider monitors closely throughout treatment.
Is Ozempic brand-name or compounded?
Premier Weight Loss prescribes only brand-name, FDA-approved Ozempic. We never use compounded alternatives. All medication arrives in original manufacturer packaging.
How much does Ozempic cost at Premier Weight Loss?
Ozempic starts at $175/month at Premier Weight Loss, up to 75% less than retail pharmacy prices. Final pricing depends on dose and is confirmed with your provider during the consultation. Available via virtual care, shipped to your Indiana address.
How is Ozempic different from the other GLP-1s you prescribe?
Ozempic (semaglutide) acts on the GLP-1 receptor alone. Tirzepatide (Mounjaro, Zepbound) is dual-action (GIP + GLP-1) and typically shows higher weight loss in trials. Your provider will recommend the best option based on your goals, health profile, and treatment response.
Other Medications We Prescribe
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Reserve a $45 consult. Your provider will confirm the right medication and dose for you.