Medical Weight Loss in Indianapolis
Brand-name GLP-1 medications — Mounjaro®, Zepbound®, Wegovy®, and Ozempic® — prescribed directly from our Indianapolis clinics at up to 75% less than retail pharmacies. Physician-supervised care with body composition tracking.
500+
Patients Treated
4.9★
Patient Rating
Board-Certified
Medical Director
In-Person & Telehealth
Statewide Indiana
Choose Your Medication
Our medical team will recommend the best option based on your goals, health profile, and treatment response.
Tirzepatide
Mounjaro®
Dual-action weight loss with blood sugar control.
Avg loss
20–22%
Frequency
Weekly
$275/mo
vs $1100 retail
Learn more →Tirzepatide
Zepbound®
Most EffectiveFDA-approved specifically for chronic weight management.
Avg loss
20–22%
Frequency
Weekly
$275/mo
vs $1050 retail
Learn more →Semaglutide
Wegovy®
The proven GLP-1 for weight loss with cardiovascular benefits.
Avg loss
15–17%
Frequency
Weekly
$175/mo
vs $1350 retail
Learn more →Semaglutide
Ozempic®
Most PopularThe original semaglutide. Off-label for weight loss with proven results.
Avg loss
14–15%
Frequency
Weekly
$175/mo
vs $1000 retail
Learn more →
How GLP-1 Medications Work
GLP-1 receptor agonists mimic a natural hormone your body produces, working with your biology not against it.
Reduces Hunger Signals
GLP-1s act on the appetite centers of your brain, reducing food noise and helping you feel full faster, longer.
Slows Digestion
Slower gastric emptying means food stays in your stomach longer, sustaining fullness and stabilizing energy between meals.
Regulates Blood Sugar
GLP-1s improve insulin response and reduce glucagon, helping blood sugar stay steady and supporting fat metabolism.
Compare All Options
All four are FDA-approved, brand-name, prescribed in clinic, and never compounded.
| Medication | Generic | Mechanism | FDA Indication | Avg Weight Loss | Dosing |
|---|---|---|---|---|---|
| Mounjaro® | Tirzepatide | Dual GIP / GLP-1 receptor agonist | Type 2 Diabetes | 20–22% | Weekly subcut. injection |
| Zepbound® | Tirzepatide | Dual GIP / GLP-1 receptor agonist | Chronic weight management | 20–22% | Weekly subcut. injection |
| Wegovy® | Semaglutide | GLP-1 receptor agonist | Chronic weight management | 15–17% | Weekly subcut. injection |
| Ozempic® | Semaglutide | GLP-1 receptor agonist | Type 2 Diabetes | 15–17% | Weekly subcut. injection |
Medically reviewed by Dr. Scott Friedman, MD ·
Common Questions
Which GLP-1 medication is most effective?
Tirzepatide (Mounjaro/Zepbound) has shown the highest weight loss in clinical trials at 20 to 22% body weight, while semaglutide (Wegovy/Ozempic) typically delivers 14 to 17%. Your medical team will recommend the best option based on your goals and health profile.
Are these medications brand-name or compounded?
Premier Weight Loss prescribes only brand-name, FDA-approved GLP-1 medications. We never use compounded alternatives. All medications come in their original manufacturer packaging.
How are you cheaper than retail pharmacies?
Most retail pharmacies focus on insurance billing rather than the best cash-pay price. Premier utilizes options like NovoCare, LillyDirect, and physician-directed off-label dosing to make brand-name medication treatment more affordable.
Do I need to choose a medication before my appointment?
No. Your medical team will recommend the best medication and starting dose for you during your initial visit, based on your goals, medical history, and any contraindications.
What are the most common side effects?
Nausea, mild GI changes, constipation, and occasional acid reflux are most common, especially in the first few weeks. Most resolve with dose adjustment, hydration, increased fiber and protein, and time. Severe side effects are rare and your provider monitors closely throughout treatment.
Can I get GLP-1 medication delivered via telehealth?
Yes. Zepbound, Wegovy, and Ozempic can all be prescribed via virtual visit and shipped to your door. Mounjaro requires an initial in-clinic visit. Virtual patients also receive a free $379 InBody H30 body composition scale.
What 15–22% Weight Loss Looks Like
Based on a 250 lb starting weight. Individual results vary based on starting weight, adherence, and lifestyle factors.
Semaglutide
Wegovy · Ozempic
37–42 lbs
15–17% body weight loss
Tirzepatide
Mounjaro · Zepbound
50–55 lbs
20–22% body weight loss
Pair Weight Loss with Aesthetic Care
Members save up to 35% on every aesthetic treatment.
- Featured
RF Microneedling
Morpheus8®
Radiofrequency microneedling for skin tightening, texture refinement, and collagen stimulation. Pair with GLP-1 to address loose skin during rapid weight loss.
Learn about Morpheus8 → - Popular
Injectables
Botox®
Smooth fine lines and wrinkles with precision injections. Member rate $11–12/unit. Performed only by licensed medical professionals under physician supervision.
Learn about Botox →
Tools & Education
Blog & Guides
Expert articles on GLP-1, nutrition, and weight loss.
View →
Dietitian Webinars
Free live + on-demand sessions for members.
View →
Healthy Recipes
High-protein, GLP-1-friendly meals.
View →
GLP-1 Quiz
Eligibility screen in under 2 minutes.
View →
BMI Calculator
Calculate your BMI and see how it relates.
View →
Serving All of Central Indiana
In-clinic care at two Indianapolis-area locations, plus virtual care statewide for any Indiana resident.
- Indianapolis
- Carmel
- Fishers
- Noblesville
- Westfield
- Zionsville
- Greenwood
- Avon
- Brownsburg
- Lawrence
- Anderson
- Bloomington
- Columbus
- Muncie
- Plainfield
- Speedway
- Beech Grove
- McCordsville
- Geist
- Cumberland
- Whitestown
- Lebanon
- Pendleton
- Greenfield
- Mooresville
- Danville
- Bargersville
- Franklin
Ready to Start Your Weight Loss Journey?
Final medication recommendations are made individually during your consultation. $45 secures your spot and applies in full to your first visit.