Supplements can be a great tool in your toolkit while trying to lose weight. They can support (but not replace) key lifestyle changes like nutrition and exercise. It’s important to note that not all supplements are created equal! They vary significantly in both quality and bioavailability – which simply means how well your body can absorb and use the nutrients. Some supplements are highly bioavailable and go straight to work, while others pass through your system with little effect. That’s why it’s important to choose supplements that are properly sourced and free from unnecessary additives and fillers. Below we will share a few quality supplements that can support your health and weight loss journey – plus a quick look at which ones to skip!
PERFECT AMINOS
Perfect Aminos is a supplement made up of eight essential amino acids (the building blocks of protein) in the exact ratio your body needs to build and repair protein structures – like muscle. Unlike standard protein powders or foods, which require digestion and can vary in how efficiently they’re absorbed. Perfect Aminos are 99% bioavailable. That means your body will use almost all of what you take in, making it extremely efficient, especially during weight loss when preserving lean muscle is key!
Muscle Mass is metabolically active tissue, which helps keep your metabolism strong even as you lose fat. Perfect Aminos also help reduce post-workout soreness and support better recovery. Many users report increased energy and fewer cravings, likely because amino acids also support neurotransmitter production and blood sugar balance.
For people on GLP-1 medications, which can cause muscle loss over time, Perfect Aminos are a fantastic tool to help protect muscle and maintain long-term strength and metabolism. They’re best taken on an empty stomach, first thing in the morning and before bed to support muscle repair while you sleep.
CREATINE
Creatine is one of the most studied and trusted supplements for improving physical performance and supporting lean muscle development. It helps your body regenerate ATP, the main energy source your muscles use during high-intensity activity like strength training.
While creatine is often associated with athletes, it’s incredibly helpful for anyone on a weight loss journey, especially those using GLP-1 medications. One of the lesser-known side effects of GLP-1s is the potential for muscle loss, particularly if you’re losing weight quickly or not consuming enough protein. Creatine helps counteract this by supporting strength and lean muscle retention, which in turn helps maintain a healthy metabolism.
It can also improve exercise performance, giving you more strength and stamina to stay consistent with workouts—even if your appetite or energy levels are lower on a GLP-1. Bonus: there’s emerging research that creatine supports cognitive function, which can help with focus and mood—both of which can fluctuate with appetite changes or calorie reduction. A daily dose of 3–5 grams is safe, effective, and easy to add to your routine.
MAGNESIUM GLYCINATE
Magnesium plays a crucial role in over 300 biochemical reactions in the body, including those related to energy production, insulin regulation, muscle function, and nervous system support. When it comes to weight loss, magnesium is especially helpful because it helps manage cortisol (the stress hormone), improves sleep quality, and can reduce cravings—especially for sugar or chocolate.
For people on GLP-1 medications, magnesium glycinate can be a game-changer. GLP-1s often slow down digestion and reduce appetite, which can lead to constipation, poor sleep, or increased stress if not managed well. Magnesium glycinate is a gentle, highly absorbable form that helps relax muscles (including the digestive tract), ease anxiety, and promote deeper, more restorative sleep.
Since GLP-1s can sometimes cause fatigue or make it harder to unwind at night, magnesium helps offset those effects naturally. It also supports stable blood sugar and insulin sensitivity, which helps your body respond better to the metabolic shifts happening during weight loss. Unlike other forms of magnesium, glycinate is easy on the stomach and typically doesn’t cause laxative effects, making it a safe, soothing addition to a GLP-1-friendly supplement stack. Take it at night for optimal calm and improved sleep quality.
SUPPLEMENTS TO SKIP
While there are many supplements marketed for weight loss, not all of them are helpful—or safe. In fact, some can actually work against your goals or create unwanted side effects.
One major category to be cautious about is fat burners. These often contain high doses of stimulants like caffeine or synephrine, which can increase heart rate, cause anxiety, and disrupt sleep. They may offer short-term appetite suppression or energy boosts, but the effects rarely last and can stress your nervous system.
Another trend to steer clear of is detox teas or cleanses. These typically act as laxatives or diuretics, causing temporary water loss rather than true fat loss. They can also lead to dehydration and electrolyte imbalances, which can be especially risky if you’re already experiencing digestive changes from a GLP-1 medication.
Lastly, appetite suppressants, especially those sold online or without regulation, can interfere with the natural appetite regulation that GLP-1s are designed to support—and may lead to excessive restriction, fatigue, or nutrient deficiencies. Instead of chasing quick fixes, focus on supplements that support your body in sustainable ways, like preserving muscle, supporting sleep, and reducing stress. Your weight loss journey should leave you feeling stronger, not depleted.
In conclusion, supplements can be a powerful part of your weight loss journey – especially if you’re using GLP-1 medications. The key is choosing products that are high – quality, well-absorbed, and aligned with your body’s needs. Supplements like Perfect Aminos, creatine, and magnesium glycinate are backed by science and support the systems that matter most: muscle, metabolism, and recovery.
To make high-quality supplementation easier and more affordable, we’ve partnered with Fullscript—a trusted platform for professional-grade supplements. As a Premier Weight Loss member, you’ll get exclusive access to top-tier products at a discounted price. If you are a member, an account has been created for you with the following username and password information:
FULLSCRIPT x PWL
Username: Email
Password: first name + last 4 digits of your phone number – if you have trouble logging in, simply push “forgot my password” to reset!
Skip the fads and focus on sustainable support. You deserve a supplement routine that helps you feel energized, resilient, and strong as you reach your goals.