GLP-1 medications, also known as glucagon-like peptide-1 receptor agonists mimic the action of the natural hormone GLP-1 released by the small intestine in response to food. These medications have been growing in popularity for their effectiveness in treating type 2 diabetes, obesity, and have recently been approved for treatment of sleep apnea. In this post, we’ll break down the science behind how these medications work and why they are so effective in promoting weight loss and improving metabolic health.
What is GLP-1?
GLP-1 is a naturally occurring hormone in the body, released by the small intestine in response to food. When food enters the stomach, GLP-1 is released and helps the body manage glucose by stimulating insulin release and preventing excess glucose from being released into the bloodstream. Additionally, GLP-1 signals the brain to reduce hunger, helping with appetite control.
How GLP-1 Medications Work
GLP-1 medications mimic the effects of the natural GLP-1 hormone. Here’s how they work:
- Insulin production – GLP-1 medications stimulate the pancreas to release insulin in response to elevated blood glucose levels. This helps lower blood sugar and improves the body’s ability to use food for energy, which is especially beneficial for people with type 2 diabetes.
- Blocking glucagon secretion – Glucagon is the hormone used to raise blood sugar levels. GLP-1 prevents more glucose from going into your bloodstream, resulting in improved blood sugar control.
- Delayed gastric emptying – By slowing digestion, GLP-1 medications reduce the speed at which glucose enters the bloodstream. This helps to stabilize blood sugar levels and prolong feelings of fullness, reducing overall food intake.
- Satiety – GLP-1 medications send signals to your brain that tell your body that you are satiated. This makes you feel fuller for longer periods after eating, which helps curb overeating and contribute to weight loss.
Evidence Supporting GLP-1 Medications for Weight Loss
GLP-1 medications were developed as a treatment option for Type 2 diabetes, but researchers soon began noticing their positive effects on weight loss. Today, many GLP-1’s are approved to treat weight loss. With the rise in awareness of their weight loss benefits, these medications have become a very popular option for weight loss.
Safety and Side Effects of GLP-1 Medications
While GLP-1 medications are generally safe, they may cause some side effects, particularly when starting treatment. Common side effects include nausea, diarrhea, and abdominal discomfort. These side effects usually subside as the body adjusts to the medication.
It’s important to be monitored by a healthcare provider while using GLP-1 medications, especially when it comes to maintaining proper nutrition. Adequate protein intake is essential to preserve muscle mass during weight loss. Additionally, GLP-1 medications are not suitable for everyone. Individuals with the following should double check with their Doctor and make sure the benefits outweigh the risks:
- Have a history of medullary thyroid cancer or a family history of the disease
- Have had pancreatitis or other pancreatic conditions
- Are pregnant or breastfeeding
Conclusion
In conclusion, GLP-1 medications have proven to be a game-changer for weight loss and improving metabolic health. By mimicking the body’s natural GLP-1 hormone, these medications aid in regulating blood sugar, appetite control, and enhanced satiety, offering significant benefits for those struggling with weight management. However, like any medication, they come with potential side effects and considerations, making it essential to consult with a healthcare provider before starting treatment. Our providers at Premier Weight Loss are ready to consult with you and help determine if GLP-1 medications are the right choice to support your goals!
Related Reading
“Weight Loss Injections and PCOS: What You Need To Know”
“Your Questions Answered: Addressing Common Concerns About Weight Loss Injections”
Sources
- Wolters Kluwer. “GLP-1 Medications and Weight Loss: Helping Patients Navigate Beyond Trends.” Wolters Kluwer. https://www.wolterskluwer.com/en/expert-insights/glp-1-medications-and-weight-loss-help-patients-navigate-beyond-trends.
- University of Chicago Medicine. “Research on GLP-1 Drugs.” University of Chicago Medicine. https://www.uchicagomedicine.org/forefront/research-and-discoveries-articles/research-on-glp-1-drugs.
- PubMed. “The Role of GLP-1 in Diabetes and Weight Loss.” PubMed. https://pubmed.ncbi.nlm.nih.gov/9840447/.